持续滴注氟尿嘧啶治疗恶性肠梗阻~

 

　　duetoperitonealdisseminationfromgastriccancer

 

　　Shou-meiYang,Hao-binYu,Qi-yuanXu,Shi-weiLi,Wei-weiLiu,Xing-Liu,Su-yiLi*

 

　　DepartmentofMedicalOncology,AnhuiProvincialCancerHospital,AnhuiMedicalUniversity,107HuanhuRoadEast,Hefei,230031,People'sRepublicofChina

 

　　*Correspondingauthor:ProfessorSu-yiLi,DepartmentofMedicalOncology,AnhuiProvincialCancerHospital,AnhuiMedicalUniversity,107HuanhuRoadEast,Hefei,230031,People'sRepublicofChina

 

　　Objective：TheaimofthisstudywastoevaluatetheefficacyandsafetyofContinuous5-fluorouracilinfusioninmalignantbowelobstructionduetoperitonealdisseminationfromgastriccancer.

 

　　Methods:Twenty-forgastriccancerpatientsdiagnosedwithmalignantbowelobstructionduetoperitonealdisseminationweretreatedwithcontinuous5-FUinfusion(300mg/m2daily)d1-5,8-12,q3w.Theprimaryendpointwassymptomcontrol(remissionofobstruction).Thesecondaryendpointwasthesymptomcontroltimeandsurvival,andthetertiaryendpointwasadverseeffects.

 

　　Results:Twenty-fourpatientsunderwentthetreatment.Pretreatment,18/24patients(75.0%)werenilperos,6/24(25.0%)drankliquids.Aftercontinuous5-fluorouracilinfusion,only4/24(16.7%)wasstillnilperos,4/24(16.7%)drankliquids,5/24(20.8%)atesoftsolids,and11/24(45.8%)ateafulldiet.Theimprovementinabilitytoeatusingthescoringsystemwasstatisticallysignificant(p<0.0001).MedianremissiontimeofMBOwas163.0days.Mediansurvivalwas100days.Three-monthsurvivalratewas54.2%andsix-monthsurvivalratewas45.8%.Treatmentwaswelltolerated,withgradeIIItoxicitiesconsistingofthrombocytopeniain2patient(8.3%),andmucositisin3patient(12.5%).

 

　　Conclusions:Continuous5-FUinfusioniswelltoleratedandshowsactivityinmalignantbowelobstructionduetoperitonealdisseminationfromgastriccancer.Continuous5-FUinfusionprovidesarationaleforexploringthisassociationinthefuture.

 

　　KeyWords:GastricCancer,Malignantbowelobstruction,peritonealdissemination,Chemotherapy,5-fluorouracil